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Wednesday, May 20, 2020 | History

3 edition of A systems analysis of the erythropoietic responses to weightlessness found in the catalog.

A systems analysis of the erythropoietic responses to weightlessness

A systems analysis of the erythropoietic responses to weightlessness

Volume I. Mathematical model simulations of the erythropoietic responses to weightlessness

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Published by Management and Technical Services Company, National Aeronautics and Space Administration] in [Houston, TX], [Washington, DC .
Written in English

    Subjects:
  • Blood -- Diseases.,
  • Weightlessness.,
  • Biological effects.,
  • Blood volume.,
  • Erythrocytes.,
  • Hematocrit ratio.,
  • Hematopoiesis.,
  • Hemoglobin.,
  • Mathematical models.,
  • Simulation.,
  • Systems analysis.,
  • Weightlessness.

  • Edition Notes

    Microfiche. [Washington, D.C. : National Aeronautics and Space Administration], 1985. 2 microfiches.

    Other titlesMathematical model simulations of the erythropoietic responses to weightlessness.
    StatementJoel I. Leonard.
    SeriesNASA-CR -- 171890., NASA contractor report -- NASA CR-171890.
    ContributionsManagement and Technical Services Company., United States. National Aeronautics and Space Administration.
    The Physical Object
    FormatMicroform
    Pagination1 v.
    ID Numbers
    Open LibraryOL16157142M

      CONCLUSION: ITACA is an internally-validated predictive SS of ESA response in real-life 'good risk' MDS patients derived from a large international dataset that surpasses others. The incorporation of biologic markers to better identify non-responders is still by: 7. The What & Why Also called Gunther's Disease Inherited disease (autosomal recessive) Deficiency in uroporphyrinogen III synthase (UROS) Increased production of porphyrins from the bone marrow, accumulation throughout the body A Diagnosis CEP is suspected in individuals (usually.

    A feedback loop involving erythropoietin helps regulate the process of erythropoiesis so that, in non-disease states, the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to sustain adequate tissue oxygen levels but not so high as to cause sludging, thrombosis, or stroke. Erythropoietin is produced in the kidney and liver in response to low .   The secondary analysis of the TREAT study does not seem to support that high ESA doses are toxic per se: the difference in darbepoetin alfa doses between the ‘good’ and ‘bad’ responders was not very impressive (only 65 μg monthly) with a substantial overlap between the two groups [11]. Moreover, the group having a good initial response Cited by: 8.

    However, there is substantial individual variability in performance enhancement, due at least in part, to different erythropoietic (EPO) responses to altitude. Animal studies suggest that the EPO response to hypoxia may be transcriptionally regulated (Ou, et al, ), and thereby influenced by . Congenital erythropoietic porphyria (CEP) is a rare, hereditary disease of cattle, pigs, cats, and people that results from a significant yet variable decrease in uroporphyrinogen III synthase (URO-synthase) activity. URO-synthetase is the fourth enzyme in the heme biosynthesis pathway, and it normally converts hydroxymethylbilane to uroporphyrinogen III.


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A systems analysis of the erythropoietic responses to weightlessness Download PDF EPUB FB2

A systems analysis of the erythropoietic responses to weightlessness: Volume I. Mathematical model simulations of the erythropoietic responses to weightlessness Author: Joel I Leonard ; Management and Technical Services Company. A systems analysis of the erythropoietic responses to weightlessness.

Volume 2: Description of the model of erythropoiesis regulation. Part A: Model for regulation of erythropoiesis. Part B: Detailed description of the model for regulation of erythropoiesis: NTRS Full-Text: View Document [PDF Size: MB] Author and Affiliation:Author: J.

Leonard. A systems analysis of the erythropoietic responses to weightlessness: Volume II. Description of the model of erythropoiesis.

[Joel I Leonard; Management and Technical Services Company. A systems analysis of the erythropoietic responses to weightlessness. Volume 2: Description of the model of erythropoiesis regulation. Part A: Model for regulation of : J. Leonard. A Systems Analysis of the Erythropoietic Responses F to Weightlessness Beginning in and continuing to the present, a systems analysis research program has focused on the hematological problems of space flight.

Specifically, it was desired to understand the mechanisms underlying the most. A systems analysis of the erythropoietic responses to weightlessness. Volume 1: Mathematical model s. In the longer run, Systems Interrelations of Gravity Responses atrophy of back and leg muscles ensues.

After return from microgravity, fatigability of scarcely used muscle groups is increased, and their peak force is : H. Hinghofer-Szalkay. This second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors.

Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are.

Abstract. Included in the report are: (1) review of the erythropoietic mechanisms; (2) an evaluation of existing models for the control of erythropoiesis; (3) a computer simulation of the model's response to hypoxia; (4) an hypothesis to explain observed decreases in red blood cell mass during weightlessness; (5) suggestions for further research; and (6) an assessment of the role that systems Author: J.

Leonard. Keighley et al (3) have described differences in the erythropoietic responses to erythropoietin (ESF) in the fasted, specific pathogen-free rat and the conventional rat.

Therefore, ESF, a hormone activated or produced by the kidney, was studied in these animals and this report describes particularly the differences in erythropoietic response to Author: Edwin A.

Mirand, Albert S. Gordon, Gerald P. Murphy. The studies include development and validation of a model of erythropoiesis regulation, analysis of the behavior of erythropoiesis under a variety of conditions, simulations of bed rest and space.

Erythropoiesis model simulation of BMC day bedrest study. Simulation o[ the hematological response to weightlessness accord with the suggestion that a decrease in red cell production of about 25% could account for the results of the day BCM by: 8.

Non–placebo-controlled trials of erythropoiesis-stimulating agents (ESAs) comparing lower and higher hemoglobin targets in patients with chronic kidney disease indicate that targeting of a lower hemoglobin range may avoid ESA-associated by: Audio Books & Poetry Community Audio Computers & Technology Music, Arts & Culture News & Public Affairs Non-English Audio Spirituality & Religion.

Librivox Free Audiobook. Podcasts. Featured software All software latest This Just In Old School Emulation MS-DOS Games Historical Software Classic PC Games Software Library. in elucidating erythropoietic mechanisms and responses, and were used for example to illustrate the normal marrow's capacity to upregulate erythropoiesis 7–8 fold in the presence of adequate iron [17].

Models of iron kinetics are fairly complex, however [15,18], leading to a somewhat cumbersome instrument, and ferrokinetic. Mammalian erythropoiesis is a conserved process tightly controlled by the hypoxia-inducible factor (HIF1) pathway.

In this study, a small molecule inhibitor (PHI-1) of prolyl-hydroxylase-2 (PHD2) enzyme involved in regulating HIF1α levels was orally administered to male BALB/c mice at 10 and 30 mg/ by: 1. Review Article Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response 1 andKanjakshaGhosh 2 Department of Haematogenetics, National Institute of Immunohaematology (ICMR), KEM Hospital, Parel,Mumbai, India Surat Raktadan Kendra & Research Centre, Udhna Khatodara Urban Health Centre, Udhna Magdalla.

Factor needed ofErythropoiesis 1. Erythropoietin (Released in response to Hypoxia) 2. Vitamin B 6 (Pyridoxine) 3. Vitamin B 9 (Folic Acid) 4. Vitamin B 12 (Cobolamin) Essential for DNA synthesis and RBC maturation 5.

Vitamin C Helps in iron absorption (Fe+++ Fe++) 6. Proteins Amino Acids for globin synthesis 7. Start studying Erythropoiesis (Negative Feedback Loop). Learn vocabulary, terms, and more with flashcards, games, and other study tools. This text presents the basic theory and practice of system dynamics.

It introduces the modeling of dynamic systems and response analysis of these systems, with an introduction to the analysis and design of control systems. You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read.

Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them.The above mentioned aspects of erythropoiesis were supported by the rodent malaria models which were proved to be useful in delineating the erythropoietic response followed by murine Plasmodium species.

Several strains of Plasmodium can infect mice such as P. chabaudi, P. berghei, P. yoelii, and P. by: Anemia is the primary clinical manifestation of malarial infections and is responsible for the substantial rate of morbidity. The pathophysiology discussed till now catalogued several causes for malarial anemia among which ineffective erythropoiesis being remarkable one occurs silently in the bone marrow.

A systematic literature search was performed and summarized information on erythropoietic Cited by: